We are interested in the roles that aging and obesity play in soft nanoparticle pharmacokinetics and pharmacodynamics. We work primarily with soft nanoparticles that are poly-ethylene-glycol and lipid-based. A larger part of our work is to understand how to modulate macrophage physiology using soft nanoparticles. These efforts include anti-inflammation treatments and macrophage rejuvenation strategies.   

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Current Members:

Desiree Denman (Graduate Student)

Hannah Lenkowski (Graduate Student)

Katherine Luttrell (Graduate Student)

Carter Murphy (UG)

Felicia Tan (UG)

Joshua Hilner (UG)

Allison Turner (UG)

Lila Hess (UG)

Ryder Duplessis (UG)

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Previous Members:

Nicole Nygen (Medical School UTHSC)

Monireh Asoudeh, Ph.D. (Stanford Medical School)

Mitch Raith, Ph.D. (Teva Pharmaceuticals)

Achal Gupta, M.S. (Unknown!)

Uche C. Anozie, Ph.D. (Vanderbilt Medical School; Post-Doc)

Jennifer Buczek, D.V.M. (Grad school somewhere!)

Sid Mahajan, B.S. (St. Judes; Medical Student)

Alex Meyers, Ph.D. (Meati Foods; Metabolic Engineer)

Kevin Quigley, Ph.D. (Safety Partners, Inc.; Team Leader and Safety Consultant) 

Megan Yang, M.S. (Axiom Space)

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Recent Papers:

PEGylated nanoparticles interact with macrophages independently of immune response factors and trigger a non-phagocytic, low-inflammatory response

         Monireh Asoudeh,* Nicole Nguyen,* Mitch Raith, Desiree S. Denman, Uche C. Anozie, Mahshid Mokhtarnejad, Bamin Khomami, Kaitlyn M. Skotty, Sami Isaac, Taylor Gebhart, Lauren Vaigneur, Aga Gelgie, Oudessa Kerro Dego, Trevor Freeman, Jon Beever, and Paul Dalhaimer

         Journal of Controlled Release 366, 282-296 (2024)

DOI: 10.1016/j.jconrel.2023.12.019

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Obesity and inflammation influence pharmacokinetic profiles of PEG-based nanoparticles

Mitch Raith, Nicole Nguyen, Sarah J. Kauffman, Namgoo Kang, Jimmy Mays, and Paul Dalhaimer.

Journal of Controlled Release 355, 434-445 (2023)

DOI: 10.1016/j.jconrel.2023.02.007

 

Interactions of Apolipoproteins with lipid-based nanoparticles

Paul Dalhaimer, Brice Florey, Sami Isaac

A.C.S. Nano 17, 837-842 (2023)

https://doi.org/10.1021/acsnano.2c10790

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Tetra-primer amplification-refractory system (ARMS) – PCR for genotyping mouse leptin gene mutation

Jiangang Chen, Xinyun Xu, Paul Dalhaimer, and Ling Zhao

Animals 5, 2680 (2022)

DOI: 10.3390/ani12192680

 

All-atom molecular dynamics simulations of poly-ethylene-glycol (PEG) and LIMP-2 reveal that PEG penetrates deep into the proposed cholesterol-transport tunnel

Paul Dalhaimer and Kate Blankenship

A.C.S. Omega 7, 15728-15738 (2022)

https://doi.org/10.1021/acsomega.2c00667

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Autophagy in cancer chemotherapy drug resistance

Monireh Asoudeh and Paul Dalhaimer

Scientific Letters 1, 4 (2022)

https://doi.org/10.48797/sl.2022.10

 

Elongated PEO-based nanoparticles bind the high-density lipoprotein (HDL) receptor scavenger receptor class B I (SR-BI)

Mitch Raith, Sarah J. Kauffman, Monireh Asoudeh, Jennifer A. Buczek, Nam-Goo Kang, Jimmy W. Mays, and Paul Dalhaimer

Journal of Controlled Release 337, 448-457 (2021).

https://pubmed.ncbi.nlm.nih.gov/34352314/

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Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel Klionsky et al. … Uche C. Anozie … Paul Dalhaimer…

         Autophagy 17, 1-382 (2021).

      https://pubmed.ncbi.nlm.nih.gov/33634751/

 

Equilibrium binding of isolated and in-plasma high-density lipoprotein (HDL) to polystyrene nanoparticles

Uche C. Anozie, Kevin J. Quigley, Aaron Prescott, Steven M. Abel, and Paul Dalhaimer

         Journal of Nanoparticle Research 22, 223 (2020)

doi: 10.1007/s11051-020-04953-0

https://link.springer.com/article/10.1007/s11051-020-04953-0

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